COVID-19 Animal Models and Vaccines: Current Landscape and Future Prospects

COVID-19 Animal Models and Vaccines: Current Landscape and Future Prospects

Blog Article

The worldwide pandemic of coronavirus disease 2019 (COVID-19) has become an unprecedented challenge to global public health.With the intensification of the COVID-19 epidemic, the development of vaccines and therapeutic drugs against the etiological agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is also widespread.To prove the effectiveness and safety of these preventive vaccines and DSLR Lens therapeutic drugs, available animal models that faithfully recapitulate clinical hallmarks of COVID-19 are urgently needed.Currently, animal models including mice, golden hamsters, ferrets, nonhuman primates, and other susceptible animals have been involved in the study of COVID-19.Moreover, Work Gloves 117 vaccine candidates have entered clinical trials after the primary evaluation in animal models, of which inactivated vaccines, subunit vaccines, virus-vectored vaccines, and messenger ribonucleic acid (mRNA) vaccines are promising vaccine candidates.

In this review, we summarize the landscape of animal models for COVID-19 vaccine evaluation and advanced vaccines with an efficacy range from about 50% to more than 95%.In addition, we point out future directions for COVID-19 animal models and vaccine development, aiming at providing valuable information and accelerating the breakthroughs confronting SARS-CoV-2.